Depression is like a persistent cloud that hangs over someone's emotions and thoughts. It's not just feeling sad occasionally; rather, it's a complex mental health condition characterized by prolonged feelings of sadness, hopelessness, and loss of interest in things that used to bring joy. Even though the symptoms of depression might come and go, a recent study published in Nature by Charles J. Lynch and colleagues, suggests that the way the brain is wired may remain the same throughout life, even when someone is not feeling depressed. So how does the brain change and how are the connections between different brain regions stronger or weaker?